Genomics, Epigenetics & Synthetic Biology
Part II Plant Sciences Module L1
Synthetic Biology: Prof. Jim Haseloff
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Lecture 1: Genetic modification in agriculture and the advent of Synthetic Biology
Origins of agriculture
Selection and breeding of new crop varieties
Industrialisation of agriculture
Genetic modification (GM) for plant improvement
Advent of Synthetic Biology

Lecture 2: Genetic circuits and genome scale DNA engineering
BioBricks, standardisation and social engineering
Type IIS assembly and common syntax
Smart DNA registries and software tools
Chromosome engineering
Reprogramming metabolic pathways in plants
Implementing plant pathways in microbes
Lecture 3: Engineered logic and the control of gene expression
Cell autonomous genetic logic
Microbial test systems
Feedback regulation: toggle switches
Transcription networks: Genetic oscillators
In vitro systems for rapid testing
Complex circuit design

Lecture 4: Self-organisation and reprogramming of multicellular systems
Organisation of natural microbial populations
Natural cell-cell signalling systems
Cellular coupling of genetic circuits
Edge detector
Coupled oscillators
Long-distance signalling
Population toggle switch
Self organising Turing patterns
Prospects for plant engineering
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Lecture 1 handout
CLICK HERE to download PDF version of the lecture handout.
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Lecture 2 handout
CLICK HERE to download PDF version of the lecture handout.
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Lecture 3 handout
CLICK HERE to download PDF version of the lecture handout.
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Lecture 4 handout
CLICK HERE to download PDF version of the lecture handout.
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Extract from a special Synthetic Biology edition of Science

The Allure of Synthetic Biology; The Life Hacker; Algae’s Second Try; A Lab of Their Own; Visions of Synthetic Biology
REVIEWS
Synthetic Biology: Integrated Gene Circuits, N. Nandagopal and M. B. Elowitz
Synthetic Biology Moving into the Clinic, W. C. Ruder et al.
PERSPECTIVE
Bottom-Up Synthetic Biology: Engineering in a Tinkerer’s World P. Schwille
POLICY FORUM
Synthetic Biology: Regulating Industry Uses of New Biotechnologies, B. Erickson et al.

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